oxysterol binding protein like 2

ORP2; ORP-2; DFNA67; DNFA67

Q9H1P3

BC000296

>85%, as determined by Coomassie blue stained SDS-PAGE

Escherichia coli

His tag C-Terminus, GST tag N-Terminus

This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain, although the encoded protein contains only the sterol-binding domain. In vitro studies have shown that the encoded protein can bind strongly to phosphatic acid and weakly to phosphatidylinositol 3-phosphate, but cannot bind to 25-hydroxycholesterol. The protein associates with the Golgi apparatus. Transcript variants encoding different isoforms have been described.

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